| Rank | Weekend Total | Weeks | Screens | Weekend screen avg. | Cumulative
box office |
|---|
| 1. | Clash of the Titans (2010) |
| $61,235,105(%) | 1 | 3,777 | $16,212 | $63,890,110 |
| 2. | Why Did I Get Married Too? (2010) |
| $29,289,537(%) | 1 | 2,155 | $13,591 | $29,289,537 |
| 3. | How to Train Your Dragon (2010) |
| $29,010,044(-34%) | 2 | 4,060 | $7,145 | $92,135,916 |
| 4. | The Last Song (2010) |
| $16,007,426(%) | 1 | 2,673 | $5,988 | $25,395,041 |
| 5. | Alice in Wonderland (2010) |
| $8,208,060 (-54%) | 5 | 2,980 | $2,754 | $309,733,753 |
| 6. | Hot Tub Time Machine (2010) |
| $8,070,716 (-42%) | 2 | 2,771 | $2,912 | $27,910,213 |
| 7. | The Bounty Hunter (2010) |
| $6,091,907 (-49%) | 3 | 3,118 | $1,953 | $48,853,453 |
| 8. | Diary of a Wimpy Kid (2010) |
| $5,302,369 (-48%) | 3 | 2,842 | $1,865 | $46,013,347 |
| 9. | She's Out of My League (2010) |
| $1,516,952 (-57%) | 4 | 1,390 | $1,091 | $28,712,974 |
| 10. | Shutter Island (2010) |
| $1,488,403 (-53%) | 7 | 1,356 | $1,097 | $123,440,937 |
